[France] PhD scholarship in Biochemistry, Saclay

Institute of Nuclear Sciences, France has been announced for PhD scholarship in Biochemistry / Life Sciences, Structural biology / Life Sciences for academic year 2011

The objectives of this project is to express and purify various Ca2+-ATPases by using the procedure developped in our laboratory in an heterologous system in yeast (Jidenko et al., PNAS, 2005) allowing the obtention of crystals able to diffract X-rays. Their structural and functional characterization will be performed. During the thesis the a main effort will be focused on human SERCA3 . Mutation of this gene have been found in patients suffering from type II diabetis.
The work will be

to clone this isoform in view of heterologous expression in yeast and trials of expression.
scale up the procedure to obtain large amount of protein.
characterization
(crystalization trials
More Information
Contact:
Marc LE MAIRE
CNRS/Université / DSV/IBITEC-S
CEA/Saclay
Email : marc.lemaire@cea.fr
Phone: 01 69 08 62 43

University/Graduate School: Paris XI

Thesis supervisor:
Marc LE MAIRE
CNRS/Université / DSV/IBITEC-S
CEA/Saclay